Association of tumor infiltration lymphocytes and complete pathological response in breast cancer patients under neoadjuvant chemotherapy

Background: The breast cancer is the most common type of cancer in Iran. Hence determination of the optimal treatment and the contributing factors are important. The main aim in current study was to determine the association between tumor infiltration of lymphocytes (TIL) and complete pathological response in breast cancer patients after neoadjuvant chemotherapy. Methods and materials: In this comparative retrospective study, 73 consecutive patients with breast cancer who went under neoadjuvant chemotherapy and core needle biopsy in Shohada Tajrish hospital , Tehran, Iran since 2011 till 2019 were enrolled and the association between TIL and complete pathological response in patients was determined. Results: The results in this study demonstrated that 13.3% and 35.7% of those with TIL less than 10 and more than 10 had complete pathological response that showed statistically significant difference (P=0.025). Conclusion: Tumor Infiltration of lymphocytes and complete pathological response in breast cancer patients who underwent neoadjuvant chemotherapy are interrelated and TIL may be used to predict the response.